IREScentralA viral IRES family database, not just a sequence list.
IREScentral organises viral internal ribosome entry site (IRES) candidates into family-centred IRES groups (IRESG): each record links member sequences, consensus structure evidence, taxonomy composition, production provenance and experimental activity context.
What one IRESG record contains
Family identity
IRESG ID, type label, Rfam anchor, evidence class and the production route that built the family.
Structure evidence
Consensus structures from up to four sources, an interactive viewer, and R-scape covariation figures where available.
Taxonomy & host
Virus family, genus and host composition aggregated over all members; orphan candidates are kept visible alongside.
Activity layer
Median reporter-assay activity over measured members, with the measured sample size always stated.
How families are built
Candidate IRES regions are extracted from viral genome 5′UTR and intergenic regions, embedded and clustered, then refined into families with calibrated covariance models (Infernal) and consensus structures checked by covariation analysis (R-scape). Each family ships with its model, seed alignment and consensus structure so results stay searchable and reproducible. See the Help & glossary for definitions.
Release status & roadmap
Currently serving v0.3. Planned for the public release: full download bundle (CM / Stockholm / FASTA), sequence similarity search, citation and DOI. Version history is on the release notes page.